The European Federation for Medicinal Chemistry (EFMC) and ChemBridge Corporation have been organising since 2004 the successful series of the International Symposium on Advances in Synthetic and Medicinal Chemistry.

Chemistry! Most students may shy away from this subject complaining that it is difficult as well as boring. Students may hate the subject especially the day before the exam but they definitely need to changetheirnotion about the subject and not consider it to be a waste.Learn Moreabout why chemistry is a part of your school curriculum.

Chemistryteaches you the ways in which the world around us works. Everything including us is made up of compounds and atoms and this is why chemistry is what teaches how the world interacts. When you understand the chemistry basics you understand the world around you.

Chemistry is sometimes referred to as central science. This is because it connectseverything to each other. Learningchemistry lets you understand geology, biology,environmentalscience , physics and many any other disciplines. When you do not have anunderstanding of basic chemistry you do not get the link to understand theotheraspects of science.

We take part in chemicalreactions each second. It is the chemical reactions that happen in thehuman body the lets us to see or move our eyes andto read apage. Even baking a cake involves many chemicalreactions. Did you know that evenwhen you breathe you make use of chemicalreactions? Thus whether you realise it or not you are using chemistry eachday of your life.

Chemistry is the explanation to everything. Why do the leaves change colour or how yourfavourite cup of coffee is made? Chemistry also has the answer to what kind of food we need in order to survive. You can have better control of the world and the thingsaround you when you have a basic understanding of chemistry.

So do not put away your chemistrytextbooks aside the next time. Learningchemistry increases yourknowledge about thingsdrastically. It lets you understand manyaspects oflife better and you can take more informed decisions now when you know chemistry.

The first edition was held in Moscow, followed by St…

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in combination with the 13th Annual Meeting of the Medicinal Chemistry Section of the Israel Chemical Society Rehovot, Israel – November 15-18, 2015 The European Federation for Medicinal Chemistry (EFMC) and ChemBridge Corporation have been organising since 2004 the successful series of the International Symposium on Advances in Synthetic and Medicinal Chemistry. The first edition was held in Moscow, followed by St….
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10th EFMC Short Course on Medicinal Chemistry Apri…
In 2009, EFMC launched a series of short courses aimed to favour cultural and scientific growth of the medicinal chemistry community and organized with affordable fees for participation. EFMC will continue the tradition in 2015, and is pleased to announce the following courses: 10th EFMC Short Course on Medicinal Chemistry Small-Molecule Modulation of Protein-Protein Interactions (PPIs) Oegstgeest (near Leiden), The…
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Molecule could treat a wide range of CNS disorders
Scientists at the Cambridge, MA, startup Sage Therapeutics have discovered an innate mechanism that indirectly influences a key receptor linked to a number of neurologic and psychiatric disorders,The psychiatric disorders can be treated with therapies like exposure therapy, cognitive behaviour and behaviour therapy to name a few. My website will also highlight about the medications that are used to treat the neurologicaldisorders. Medicationscannot help to cure the mental illness but it does help in managing the symptoms. The best way is to club medication with psychotherapy. including Alzheimer’s, schizophrenia, autism and depression. The newly discovered natural allosteric modulator influences the N-methyl-D-aspartate (NMDA) receptor, which is known to play a role in regulating synaptic function…
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Alga Provides Feasible Mass Production System for …
An algal system for manufacturing recombinant proteins has provided scientists with the means to generate a malaria-blocking vaccine candidate based on two native unglycosylated Plasmodium falciparum surface proteins, Pfs25 and Pfs28. The University of California, San Diego researchers produced the two P. falciparum proteins in the chloroplasts of the widely used model alga Chlamydomonas reinhardtii, and then injected…
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Toxins found in traditional Chinese medicine
A host of potential toxins, allergens and traces of endangered animals showed up in DNA sequencing tests on 15 Chinese traditional medicines, researchers said on Thursday. Such therapies have been used in China for more than 3,000 years, but have risen in popularity outside Asia in recent decades and now amount to a global industry worth hundreds of millions of dollars a year, according to the study in PLoS Genetics. Despite…
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Screen uncovers hidden ingredients of Chinese medi…
Genetic audit reveals that some traditional remedies contain endangered animals and toxic plants. Chinese herbal medicines contain ingredients derived from endangered animals, toxic plants and livestock, a genetic audit has discovered. Few of these ingredients were listed on the packaging. “There’s absolutely no honesty in the labelling of these products. What they declare is completely at odds with what’s in there,”…

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Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body. This discovery represents a major innovation, said Adah Almutairi, PhD, associate professor…
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Nano-paper filter removes viruses
Nanotechnology and Functional Materials, Uppsala University have developed a paper filter, which can remove virus particles with the efficiency matching that of the best industrial virus filters. The paper filter consists of 100 percent high purity cellulose nanofibers, directly derived from nature. The research was carried out in collaboration with virologists from the Swedish University of Agricultural Sciences/Swedish…
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Radiation able to be securely stored in nontoxic m…
Researchers have discovered that microscopic “bubbles” developed at Kansas State University are safe and effective storage lockers for harmful isotopes that emit ionizing radiation for treating tumors. Hop over to this web-site to understand what isotopes are. Isotope of any chemical element is an atom that consists of extra number of neutrons than the standard amount for that particular element. So basically the isotope will have the equal number of protons but it has a different number of neutrons. The isotopes thus will have the same atomic number but its mass number will be different.The findings can benefit patient health and advance radiation therapy used to treat cancer and other diseases, said John M. Tomich, a professor of biochemistry and molecular biophysics who is affiliated with the…
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Self-assembling cages built from DNA
Move over, nanotechnologists, and make room for the biggest of the small. Scientists at the Harvard’s Wyss Institute have built a set of self-assembling DNA cages one-tenth as wide as a bacterium. The structures are some of the largest and most complex structures ever constructed solely from DNA, they report online in Science. Moreover, the scientists visualized them using a DNA-based super-resolution microscopy method…
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Hair-like constructs offer drug screening platform
Scientists from A*STAR have successfully engineered cellular structures resembling hair follicles in the laboratory — a tool that can now be used to develop new therapies to promote or decrease hair growth (“Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers”). “The follicle-like structures of our model form the basis of a…
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Qualcomm to Build Neuro-Inspired Chips
The world’s largest smartphone chipmaker, Qualcomm, says it is ready to start helping partners manufacture a radically different kind of a chip—one that mimics the neural structures and processing methods found in the brain. The approach is emerging as a way to enable machines to perform complex tasks while consuming far less power. IBM has been prototyping similar chips (see “IBM Scientists Show Blueprints for…

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52nd International Conference on Medicinal Chemistry
52èmes Rencontres Internationales de Chimie Thérapeutique

The French Medicinal Chemistry Society (Société de Chimie Thérapeutique – SCT) is pleased to invite you to Caen (Normandy), France on July 6-8, 2016 for the 52nd edition of the International Conference on Medicinal Chemistry (RICT 2016).

Patrick Dallemagne, head of the Local Organising Committee will welcome you in the city of William the Conqueror, Duke of Normandy and King of England.

The congress will be devoted to “Interfacing Chemical Biology and Drug Discovery” and the main topics will be:

  • Approaches for Target Identification-Validation
  • Biomarkers – Innovative Diagnostic Approaches, Tools
  • Molecular Diversity
  • Chemoinformatics in and for Drug Discovery
  • Therapeutic Interventions Targeting the Nervous System
  • Case Studies (all targets and therapeutic indications included)

Additionally you will be able to appreciate the climate of the beautiful Normandy and visit the famous Mont-Saint-Michel,

It is important that we live in a place that has a good climate. Human activities have however released a lot of carbon dioxide and other greenhouse gases which traps heat and affects the global climate. The temperature of the earth has increased by around 1 degree in the last 130 years and every successive decade is warmer than the last one.

This causes the sea level to rise and the glaciers to melt. The pattern of precipitation is changing. The extreme events of weather are also becoming more frequent and intense. If you want to loseweight even in such extreme climatic conditions then hop over to this website.

The climate change also has a lot of impact on health. Global warming may bring some localised benefits.This could be less number of winter deaths in the temperate climates and an increase in food production in some areas.However, the overall health effects and a changing climate are likely to be negative. Climate change affects the social and the environmental determinants of health. It can affect the clean air that you breathe, leave you without safe water to drink and also not offer you secure shelter and enough food.

its wild coast with its lighthouses, the D-Day historic sites and beaches, the green countryside (here the highland named Norman Switzerland) or the lovely Alabaster seaside with the famous Etretat beach.

Caen is located at 230 kilometers from Paris and easily accessible by car, train, plane or even by boat (Caen – Ouistreham harbour).

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Grades of Chemical Reagents

Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications.

A branch of chemistry, quantitative chemical analysis lets one understand the percentage or amount of one or more components that are present in a sample. Many techniques are employed to do quantitative analysis. The methods are broadly classified as physical and chemical. This is dependent on the properties that are used.View publisher siteif you want to get information about a product that has the perfect chemical composition that helps to treat cardiovascular problems.

The chemical methods depend on reactions like oxidation, neutralization and precipitation. It also depends on the formation of a new compound. The chemical ways are known as volumetric or gravimetric analysis. In the physical method the physical property of a substance is measured. This includes its refractive index, density, polarization of light and absorption. It also includes magnetic susceptibility and electromotive force. To do a proper analysis a combination of methods are used. The qualitative method will separate the desired constituent from the sample and the quantitative method will measure the amount that is present.

Purity standards for reagents are set by organizations such as  ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent grades.

  • Reagent A.C.S. – This designates a high quality chemical for laboratory use. The abbreviation “A.C.S.,” means the chemical meets the specifications of the American Chemical Society. A Certificate of Analysis is available upon request.
  • Guaranteed Reagent (GR) – Suitable for use in analytical chemistry, products meet or exceed American Chemical Society (ACS) requirements where applicable. (EMD trademark)
  • AR – The standard Mallinckrodt grade of analytical reagents; suitable for laboratory and general use. If the reagent also meets the requirements of the American Chemical Society Committee on Analytical Reagent, it will be denoted as an AR (ACS) reagent. (MBI trademark)
  • Primary Standard – Analytical reagent of exceptional purity that is specially manufactured for standardizing volumetric solutions and preparing reference standards.
  • Reagent – The highest quality commercially available for this chemical. The American Chemical Society has not officially set any specifications for this material.
  • OR – Organic reagents that are suitable for research applications.(MBI trademark)
  • Purified – Defines chemicals of good quality where there are no official standards. This grade is usually limited to inorganic chemicals.
  • Practical – Defines chemicals of good quality where there are no official standards. Suitable for use in general applications. Practical grade organic chemicals may contain small amounts of isomers of intermediates.
  • Lab Grade – A line of solvents suitable for histology methods and general laboratory applications.
  • USP – Chemicals manufactured under current Good Manufacturing Practices and which meet the requirements of the US Pharmacopeia.
  • USP/GenAR – A line of chemicals manufactured under cGMP, meet the requirements of the 1995 USP 23, meet European Pharmacopeia (PhEur, EP) and British Pharmacopeia (BP) specifications where designated, and are Endotoxin (LAL) tested where appropriate. (MBI trademark)
  • NF – Chemicals that meet the requirements of the National Formulary.
  • FCC – Products that meet the requirements of the Food Chemical Codex.
  • CP (Chemically Pure) – Products of purity suitable for use in general applications.
  • Technical – A grade suitable for general industrial use.
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SMi will present their inaugural conference on Alzheimer’s Disease 2016, which is one of the most threatening diseases that accompanies age, yet formidably mysterious in biology.

This conference will cover: Pre-clinical assessment criteria for AD diagnosis such as risk profiling, population group assessment and stages of AD progression. How do external stimuli play influence studies and outcome?

Furthermore, emerging frontiers in biomarker development to aid more accurate diagnosis and tracking of tau-mediated neuronal death will help further drug development as well as providing more answers into how AD occurs, and most importantly when.

The conference will gather leading researchers and clinical managers to discuss models, diagnostic imaging and novel therapeutic platforms.

There is continuous research in the field of medicine andnew drugs are added regularly. Researchers are ensuring that they add new and tested drugs so that it helps to improvehealth. Thanks to technology it is alsopossible to buy these medicines online without going anywhere.However, if you choose to buy on the online sites make sure that you buy it from a genuine store only.

Try hereif you want to buy genuinesupplements to getrelieffrom pain that you experience in your feet and joints. Online pharmacy stores are popular but care should be taken to purchase from a licensed store. One doesnot get to inspect the product when they purchase it online. However,because it is about your healthyoucannot take achance. So how do you go about checking the quality of medicine that the online stores offer?

No genuine online pharmacy store willsell the medicines without a valid prescription. This is an importantaspect and if you see that a shop is ready to sell medicines without prescription then that should raise a red flag.

The second thing to check is the license that the shop has. The licensing lets you know about the store quality. The pharmacy should have the legal licenses to sell in your state and also hold a certification that promises the authenticity of the medicine.

Stay clear of anyforeign websites. One should not purchasemedicine from a foreign website which is not a part of their native country. This is because the information of the drug and thedosagewillvaryfrom one place to another and also the drug may not get delivered in the right time.

If you are not sure about a medicine then do not buy it. This can cause health risks and other complications.

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Currently, pharmaceutical companies assemble their own in-house databases of pharmacological and physicochemical data resources. Open PHACTS integrates data from multiple publicly-available databases, giving you access to a vast linked data resource through a stable, integrated infrastructure.

This allows researchers to build better analysis pipelines — and gives researchers in academia and smaller companies unprecedented access to pharmacological data resources.

What do we mean by “linked data”?

Pharmacological entities — compounds, target pathways, etc. — each have multiple different identifiers used by different data providers. This makes finding information about an entity a complicated, fragmented process. For example, Sorafenib has the following identifiers:

  • DrugBank: DB00398
  • ChemSpider: 187440
  • ChEBI: 50924
  • ChEMBL: CHEMBL1336
  • FDA: ucm376547

In fact, Sorafenib has over 30 of these identifiers, each linking to a different data provider with different bits of information about Sorafenib’s properties and actions.

The Open PHACTS Discovery Platform integrates data associated with each identifier, so that you can browse and query interoperable data about Sorafenib from multiple sources in one place. This allows you to drastically increase the efficiency of your existing research and analysis workflows.

What sort of questions can Open PHACTS answer?

The potential of Open PHACTS to facilitate research is vast. Our example Workflows demonstrate some of the questions that Open PHACTS can help answer for you as a researcher.

Research helps in informing action and to offer a theory. It is an important contribution to develop knowledge in the field of study. Research thus has a lot of significance and you can find morehere on how research got to us this excellent product to treat hearing issues.

It is a no brainer to understand why research is important but many avoid getting into this field. The field is for those who have a passion towards learning. Research is the tool that helps to build knowledge and also facilitates learning. Research is essential not just for academics and students but also for the professionals. It is important for the veteran writers too. Research helps one to understand various concerns and it increases the awareness of the public.

Be it in the field of academics or in the industry, research is a must. Industries spend a lot of money and have a dedicated team that performs research on ways to make the process more cost efficient and also more productive.

We also provide access to integrated data via the Open PHACTS Explorer and various other Applications for browsing and querying data.

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TimTec and Sigma-Aldrich (NASDAQ:SIAL) are pleased to announce the availability of the MyriaScreen Diversity Collection of drug-like screening compounds produced in collaboration, as a result of careful evaluation, filtering, and refinement of selections from each of our screening compound collections. The MyriaScreen Diversity Collection is comprised of 10,000 high-purity screening compounds handpicked to maximize chemical diversity while maintaining drug-likeness.

The MyriaScreen Diversity Collection was assembled from a pool of over 300,000 screening compounds using a combination of filters, diversity predictors, and manual selection. The resulting 10,000 compounds are drug-like, chemically diverse, and amenable to follow-up chemistry and optimization. The collection is well suited for researchers that are looking for a small, cost-effective, ready-to-screen set of high-quality screening compounds.
“MyriaScreen will complement our customers’ existing screening collections and jump-start new collections by quickly adding interesting chemotypes,” said Michael Earley, Product Manager, Drug Discovery, Sigma-Aldrich. “Our collaboration with TimTec, Inc. resulted in a high-quality library that our customers will find useful.”

About Sigma-Aldrich

Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and chemical manufacturing.

Research is an integral part of the medical field. It lets the clinicians to understand and make new discoveries. It also helps in development of drugs.Arthromedis a great product that has been manufactured with a lot of research. It is a miracle cure for joint pains. Research along with basic science helps in increasing knowledge and discovery in the field of medicine.

We have customers in life science companies, university and government institutions, hospitals and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 34 countries and has 6,000 employees providing excellent service worldwide. We are committed to the success of our Customers, Employees and Shareholders through leadership in Life Science, High Technology and Service.

To request information about MyriaScreen, please click here.

Forward Inquiries to:
Mrs. Kelley Euchner, 800-521-8956
Mr. Timothy Sommer, 314-286-7768

About TimTec

TimTec Corporation is a privately held company located in Newark Delaware, USA. It was founded in 1995 and began its work in the areas of acquisition and distribution of synthetic organic and natural compounds, custom synthesis, and laboratory equipment to become a full service partner for drug discovery. TimTec has established a global network of thousands of scientists from research centers around the world. The company has developed strong in-house expertise assembling general and targeted library collections for variety of research purposes. International customers include major pharmaceutical, biotech, agricultural, and educational companies and institutions, which use TimTec products for research and development programs.

For further information please contact:
TimTec Inc
301 A Ruthar Drive
Newark DE 19711
Tel 302 292 8500
Fax 302 292 8520
info@timtec.net
http://www.timtec.net

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Cancer Research UK has struck a deal with AstraZeneca ($AZN) to repurpose an experimental therapy originally developed by the drug giant for asthma and study its ability to fight kidney cancer.

Renal cancer or kidney cancer is a disease that occurs when the kidney cells get malignant or cancerous. When this happens then the kidney cells are not under control and they develop into a tumor. The majority of cases of kidney cancer start in the tubules which are the lining of tiny tubes present in the kidney. This is the renal cell carcinoma.

Most of the cases of kidney cancers are detected before they spread to any other organ. If the cancer is caught early then it can also be treated successfully. However, at times, the tumour may grow very large before they get detected. Most cases of health issues and their treatment plans can be read about in this directory. You should however check this space if you want a clear and blemish free skin.

Kidneys are shaped like a bean and each has the same size as that of a fist. These lie in the lower abdomen region on either side of the spine. The kidney cleans the blood and removes waste from the body. It makes urine.

There are some factors that increase the risk of one getting kidney cancer. Kidney cancer risk is higher in those who are over 40 years of age.

Under the agreement, the nonprofit’s drug development office will carry out preclinical testing and early clinical trials of the compound, AZD2098. Cancer Research UK plans to begin enrolling up to 40 patients in an early phase study in 2015

AZD2098 targets a molecule called CCR4, which is found on immune cells and helps direct these cells to where they need to go. In kidney cancer, CCR4 is thought to drive immune cells toward the tumor cell. When this happens, the tumor causes the immune cells that are redirected toward it to become inactive or, in the worst case, aid the spread of cancer.

Frances Balkwill at Queen Mary University of London’s Barts Cancer Institute, with funding from Cancer Research UK, found that AZD2098 may be able to block this function by changing the immune cell environment around the cancer, instead stimulating those cells to attack the tumor.

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SAN DIEGO, Aug. 10 /PRNewswire/ — BrainCells Inc. (BCI) today announced it has in-licensed a clinical-stage compound from Mitsubishi Pharma Corp. (MPC) that BCI will reposition and develop for the treatment of central nervous system (CNS) diseases, including mood disorders.

MPC extensively developed the compound for another CNS indication, then suspended the program when the drug met safety expectations but did not reach the defined efficacy endpoints. BCI applied its proprietary technology in the area of neurogenesis

To understand the technology of neurogenesis better it is first important to know what the process is. When new neurons get formed in the brain then this is known as neurogenesis. In this process, the neural state cells differentiate. This means that they turn into one or many numbers of specialised cell types. These are formed at specific times and specific regions in the brain. If there are weakening signals in the brain then your doctor may also prescribe to you the SkinVitalissupplement.

The process by which endogenous stem cells in the adult human brain produce new brain tissue, including neurons — to identify different indications for the drug. The company expects to begin development and initiate additional Phase 2 clinical trials of the compound, BCI-540, next year.

“This is indicative of the extensive opportunity that exists for us in the CNS drug development space,” said James A. Schoeneck, BCI’s CEO. “We can screen compounds efficiently for neurogenic properties and pursue the development of these compounds for indications that weren’t part of a licensor’s original plans. The license from MPC provides us with the ability to capitalize on the predictive power of our screening platform, enabling us to develop a novel product for CNS disorders that affect millions of patients.”

“BCI has a unique approach to the identification and development of drugs that can be repositioned for a variety of CNS diseases,” said Akihiro Tobe, managing executive officer of MPC. “We believe that BCI has the right mix of cutting-edge science and development expertise to maximize the opportunity for the compound.”

About Mitsubishi Pharma Corp.

Mitsubishi Pharma Corporation (MPC), a research-driven pharmaceutical company, is the core member in the Mitsubishi Chemical Holdings group, under which Mitsubishi Chemical, a leading chemical company in Japan, and MPC exist as wholly-owned subsidiaries. Formed in 2001 by the merger of Mitsubishi-Tokyo Pharmaceuticals & Welfide Corporation (formerly Yoshitomi), MPC is committed to scientific progress, pharmaceutical advancement and the creation of products that benefit worldwide people’s welfare. Its core therapeutic areas are psychiatric and central nervous system diseases, cardiovascular and metabolic diseases, immunological and respiratory diseases and hepatic diseases. More information about the company can be found by visiting http://www.m-pharma.co.jp/.

About BrainCells Inc.

BrainCells Inc. (BCI) is a San Diego-based drug discovery and development company that is applying proprietary neurogenesis-based technology to identify and reposition compounds for the treatment of central nervous system (CNS) diseases. With its predictive screening platform, BCI can direct the selection and development of neurogenic compounds, increasing the opportunity for successful clinical trials in a variety of CNS indications. For more information, visit http://www.braincellsinc.com.

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