Lipinski Rule-of-Five

Lipinski’s rule-of-five analysis
Christopher Lipinski’s rule-of-five analysis helped to raise awareness about properties and structural features that make molecules more or less drug-like. The guidelines were quickly adopted by the pharmaceutical industry as it helped apply ADME considerations early in preclinical development and could help avoid costly late-stage preclinical and clinical failures. This article source will help in brushingup your chemistry knowledge about molecules. So what exactly is amolecule? Molecules are formed when two or more atoms of either the same or different element get bound with each other. The molecule could either be homonuclear which meansthat it is made up of atoms of a single element only. It could also be heteronuclear which a chemical compound that is formed by molecules of two or more elements.The guidelines predict that poor absorption or permeation of a orally administered compound are more likely if the compound meets the following criteria:

* Molecular mass greater than 500 Da
* High lipophilicity (expressed as cLogP greater than 5)
* More than 5 hydrogen bond donors
* More than 10 hydrogen bond acceptors

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