Purity for use

Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications. Purity standards for reagents are set by organizations such as ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent…
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14th Cytokines & Inflammation Conference Janu…
Over the years, GTCbio’s 14th Cytokines & Inflammation Conference has become an established meeting point for academic scientists, Scientists have an important role to perform in many fields. Check the index here. This includes social science, agriculture, engineering, physical science, space research and many others. There are several job opportunities for scientists in various fields. They can find employment in private as well as government organisations. Did you know that you can also work as an academic scientist? industry clinical developers, and government researchers to discuss complementary approaches in the field of cytokine biology. We are excited to announce the 13th annual edition of this meeting, which will take place January 25-26, 2016 in San Diego, CA, so mark your calendars and save the…
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Novel Immunotherapeutics Summit January 25 –…
We invite you to GTCbio’s Novel Immunotherapeutics Summit, which takes place on January 25 – 26, 2016 in San Diego, CA. The summit will bring together our usual balance of industry and academia, so that delegates have the unique opportunity to network with colleagues from different sectors and gain a fresh perspective on the various topics below. 14th Cytokines & Inflammation This conference has become an…
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8th Ocular Diseases Drug Discovery Conference Marc…
The 8th Ocular Diseases Drug Discovery Conference is taking place on March 21-22, 2016 in San Diego, CA. Novel therapeutics from the nanotechnology scope are on the rise. The progress in drug and gene-loaded particles that adequately pass through the mucus barriers provides better delivery to ocular tissue. Recent developments in gene therapies with sustained release of a protein have shown promising results with lesser side…
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Enzymes in Drug Discovery Summit February 29 ̵…
We are excited to announce the Enzymes in Drug Discovery Summit, which will take place February 29 – March 2, 2016 in San Diego, CA. Enzymes have proven to be an important group of drug targets in diseases, and enzyme inhibitors have been among the most successful of drugs. Join us as we discuss ways to overcome drug resistance to these inhibitors, and discuss breakthroughs in targeting historically undruggable…
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10th Drug Design & Medicinal Chemistry Confer…
We are excited to announce the 10th Drug Design & Medicinal Chemistry Conference, to be held May 11-12, 2016 in Berlin, Germany. This meeting will provide a multi-disciplinary forum for industry and academia colleagues to gather and explore the changing landscape of drug discovery in emerging target classes and chemical biology approaches for discovering new medicines. Leaders in the field will present on hot topics such…
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2nd Kinase Inhibitors Design & Screening Conf…
GTCbio and the Advisory Board would like to invite you the 2nd Kinase Inhibitors Design & Screening Conference. This event takes place May 12-13, 2016 in Berlin, Germany. The conference brings together industry leaders from major pharmaceuticals, biotech companies, and top researchers from academia to provide a timely and critical update on significant kinase inhibitors and to better understand current trends for drug…
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11th Protein Kinases in Drug Discovery Conference …
We invite you to attend the 11th Protein Kinases in Drug Discovery Conference, which will take place February 29 – March 1, 2016 in San Diego, CA. Over the past decades, protein kinases have proven to be an important class of drug targets for the pharmaceutical industry. This meeting seeks to create a forum for scientists from both industry and academia to gather and discuss the most recent advances in kinase inhibitor…
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6th Ubiquitin Research & Drug Discovery Confe…
We are pleased to invite you to GTCbio’s 6th Ubiquitin Research & Drug Discovery Conference, which will take place February 29 – March 1, 2016 in San Diego, CA. This conference will provide a forum for researchers from industry and academia to learn about recent advances in basic science and drugs that target the ubiquitin/proteasome system. Hot topics such as autophagy in cancer, developments with…
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Food Safety 2016 June 06-08, 2016 London, UK
2nd International Conference on Food Safety and Regulatory Measures OMICS International Conferences invites all the participants from all over the world to attend ‘2nd International Conference on Food safety and Regulatory Measures ‘during June 06-08, 2016 at London, UK which includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions. Food Safety-2016 refers to the conditions and practices…
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Open access to integrated pharmacological data
Currently, pharmaceutical companies assemble their own in-house databases of pharmacological and physicochemical data resources. Open PHACTS integrates data from multiple publicly-available databases, giving you access to a vast linked data resource through a stable, integrated infrastructure. This allows researchers to build better analysis pipelines — and gives researchers in academia and smaller companies unprecedented…

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Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications. Purity standards for reagents are set by organizations such as ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent…
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Gene Tied to Emergence of Chemotherapy Resistance
Researchers say analyzing a particular gene in high-grade serous cancer (HGSC) could help predict whether a patient’s tumor is likely to become resistant to chemotherapy over time. Chemotherapy treatment is used to treat cancer. However there is one obstacle that could cause a challenge .Drugs resistance has been observed in those patients who are getting a chemo treatment to cure cancer. Patients start to develop resistance to the drugs that were previously effective. Once the cells start to multiply there could be more resistant cells.This post states this challenge in detail.A team headed by researchers at the Peter MacCallum Cancer Center in Melbourne, Australia, has found that the emergence of treatment resistance in HGSC is associated with a loss or downregulation of the lipid transporter LRPB1 in the tumor. …
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AstraZeneca Partners on miRNA Inhibitors
AstraZeneca is paying Regulus Therapeutics $28 million up front as part of a strategic alliance focused on the discovery and development of microRNA therapeutics against three specified targets in the fields of cardiovascular metabolic diseases and oncology. The payment from AstraZeneca will be made in the form of an equity investment and up front cash. Under terms of the deal Regulus will lead preclinical development,…
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Firms Flock to Epic’s CTC Platform
Cancer diagnostics specialist Epic Sciences reported signing collaborations with six pharma companies centered on the application of its circulating tumor cell (CTC) capture and analysis technology to identify biomarkers that can serve as the basis of companion diagnostics. The collaborations involve 12 clinical trials that are part of 40 distinct projects measuring 18 different markers. Epic was spun out of the…
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FDA Approves Tudorza Pressair for COPD
The FDA on Monday approved Tudorza™ Pressair™ (aclidinium bromide inhalation powder) for long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Forest Laboratories is distributing the drug in the U.S. under a license with Barcelona, Spain-based Almirall; the two companies co-developed the drug. Tudorza is…
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New Pig Models for Cancer Studies
A naturally occurring line of immunodeficient pigs can support the growth of human tumors injected under their skin, offering a promising new large-animal model for studying human cancers and testing new drugs and treatment strategies. The ability of human melanoma cells and pancreatic carcinoma cells to grow in these pig models is described in an article in BioResearch Open Access, a new bimonthly peer-reviewed open…
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OGT Awarded $3.6M for Next-Generation Sequencing
Oxford Gene Technology (OGT) next-generation sequencing service team has been awarded two EU-funded clinical research grants worth €3 million (approximately $3.6 million). OGT will be providing genomic analysis and commercialization services for two international studies, EUCLIDS and PATHSEEK. EUCLIDS (EU Life-threatening Infectious Disease Study), is a five-year, large-scale study to identify genomic variants that…
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Pfizer-Janssen Alzheimer’s Treatment Misses …
Pfizer said late Monday that the co-primary clinical endpoints were not met in the Phase III trial of an Alzheimer’s treatment being led by an entity of Johnson & Johnson’s Janssen Pharmaceuticals unit. Janssen Alzheimer Immunotherapy (AI) R&D joined with Pfizer in setting change in cognitive performance and functional performance compared to placebo as the co-primary endpoints in Study 302, a Phase III…
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Merck Steps Further into HIV Space
Merck & Co. expanded its reach into the HIV arena by signing two licensing agreements for investigational drug candidates. One deal is with Chimerix, based in Research Triangle Park, NC, and the other is with Yamasa of Choshi, Japan. Merck is also planning to advance an internally developed HIV candidate, MK-1439, into a Phase IIb trial. “Despite the tremendous advances made over the past 20 years, there…
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Scientists Identify Target for Obesity and Atheros…
Scientists claim that an enzyme already implicated in the control of tumorigenesis through p53 activation may also directly act to control obesity and atherosclerosis. Wip1 phosphatase is a known negative regulator of ataxia telangiectasia mutated (Atm)-dependent signaling, and knocking out the Wip1 gene, which is amplified in a range of primary human cancers, has been shown to result in tumor resistance in a number of…
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Cytotoxic Warheads at Forefront of Anticancer Coll…
Cancer Research Technology (CRT) and newly established Swiss firm ADC Therapeutics (ADCT) inked a collaboration to develop antibody-drug conjugates (ADCs) based on CRT’s antibodies and peptides, and ADCT’s anticancer cytotoxic ‘warheads’ and linker chemistries. CRT is the commercial arm of Cancer Research U.K., and holds the IP rights to a range of the latter’s tumor-targeting antibodies. Under terms of the deal…

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21st European Symposium on Quantitative Structure-



Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications. Purity standards for reagents are set by organizations such as ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent…
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21st European Symposium on Quantitative Structure-…
The EuroQSAR Symposia have been taking place since 1973 and constitute major scientific events in the field of computational drug design, with further applications in agricultural and environmental sciences. The 21st EuroQSAR 2016 symposium, entitled “Where Molecular Simulations Meet Drug Discovery” to highlight the importance of atomistic and molecular simulations in drug discovery, will take place from September 4-8,…
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EFMC ISMC 2016 International Symposium on Medicina…
The XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2016) will be organised by the Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry, on behalf of the European Federation for Medicinal Chemistry (EFMC). EFMC is the main organisation for European Medicinal Chemistry community with 25 member societies and about 7.500 members. Its biennial EFMC-ISMC is a key symposium in its…
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BOSS XV 15th Belgian Organic Synthesis Symposium J…
The BOSS-conference is a unique international symposium as it combines lectures delivered by established organic chemists as well as younger rising stars with two prestigious events: a lecture delivered by the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and the “Tetrahedron Chair”: a one-day course on a specific topic in organic synthesis. The conference will cover a broad…
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RICT 2016 Interfacing Chemical Biology and Drug Di…
52nd International Conference on Medicinal Chemistry 52èmes Rencontres Internationales de Chimie Thérapeutique The French Medicinal Chemistry Society (Société de Chimie Thérapeutique – SCT) is pleased to invite you to Caen (Normandy), France on July 6-8, 2016 for the 52nd edition of the International Conference on Medicinal Chemistry (RICT 2016). Patrick Dallemagne, head of the Local Organising Committee will…
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ECHC 2016 XXVII European Colloquium on Heterocycli…
The 27th European Colloquium on Heterocyclic Chemistry will take place in Amsterdam from July 3 to 6, 2016. The ECHC is an open meeting dealing with all aspects of heterocyclic chemistry with mainly, but certainly not only, European speakers and participants from academia and industry. The aim of the meeting is to present new results, stimulate interactions between academia and industry and create an atmosphere for…
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12th EFMC Short Course on Medicinal Chemistry Modu…
In 2009, EFMC launched a series of short courses aimed to favour cultural and scientific growth of the medicinal chemistry community and organised with affordable fees for participation. This intensive course is intended for scientists working in the field, and the presentations will be given by senior scientists from industry and academia. The number of participants will be limited to 35, to favour in depth discussion….
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MacroBeGe 2016 3rd Belgian-German Macromolecular M…
For centuries mankind has focused on developing static materials that can perform specific and increasingly more complex tasks for longer and longer timespans. However, the next level of soft matter materials are required to interact with their environment in a responsive fashion, able to adapt to changing environmental conditions as well as being able to self-mend. Ultimately, materials are desired that can also not only…
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HTC-14 14th International Symposium on Hyphenated …
HTC-14 will be the premier platform for state-of-the art developments in hyphenated separation techniques. For 3 days, Ghent will be the setting of an international scientific meeting with: 3 Parallel Sessions running full time over the 3 days 1 Session dedicated to young scientists via poster flash presentations and PhD speaker sessions 3 internationally renowned Plenary Speakers o Prof. Jim JORGENSON (University of North…
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3rd NovAliX Conference Biophysics in Drug Discover…
For the third time, NovAliX is organising its Biophysics in Drug Discovery Conference. This new edition will cover current hot topics including cryo-EM and introduce new features. Because of the ever growing success of the two first editions, we will change the venue and relocate the event to the newly renovated Strasbourg Convention Centre. The use of biophysical methods in drug discovery is rapidly increasing and the field…
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3rd Allergy, Asthma, & COPD Conference Januar…
GTCbio is delighted to present the 3rd Allergy, Asthma, & COPD Conference, to be held on January 25-26, 2016 in San Diego, CA. The conference will bring together industry, academia and government experts in the field of allergy, asthma and COPD. Experts will facilitate discourse on the challenges and opportunities for therapeutic and drug development for allergic diseases for the current and future generations. Topics…

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Billionaire backs new program for a pioneering Alz



Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications. Purity standards for reagents are set by organizations such as ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent…
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Billionaire backs new program for a pioneering Alz…
German billionaire Dietmar Hopp is adding to his multimillion-dollar wager on AC Immune, the Swiss biotech that is playing a key role in some high-profile Alzheimer’s programs. Hopp has been the primary investor behind the company, and today he joined in a $22 million D round designed to fund a new therapeutic vaccine program aimed at the memory-wasting disease. AC Immune isn’t built like most biotechs. CEO Andrea…
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Cancer Research UK will repurpose an AstraZeneca a…
Cancer Research UK has struck a deal with AstraZeneca ($AZN) to repurpose an experimental therapy originally developed by the drug giant for asthma and study its ability to fight kidney cancer. Kidney cancer is a deadly disease. It is caused when the cell’s DNA starts to mutate. This can happen in one or both the kidneys. Find more information how mutation can cause uncontrolled division of cell and its growth. It may not be known with certaintly about what could cause kidney cancer in someone. However, there definitely are some factors that are linked to the disease. Under the agreement, the nonprofit’s drug development office will carry out preclinical testing and early clinical trials of the compound, AZD2098. Cancer Research UK plans to begin enrolling up to 40 patients in an early phase…
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Alcohol-addicted rats treated with optogenetics st…
Using an emerging technique called optogenetics, which uses light to stimulate neurons, researchers at the University at Buffalo have found a way to alter alcohol drinking in rodents that mimics human binge drinking behavior. The investigators say the findings could help scientists develop new treatments for alcoholism, other addictions and neurological and mental illnesses. First, researchers trained rats to drink alcohol in…
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Illumina’s New Sequencers
The genetics world was rocked by a surprise announcement from its most prominent company: Illumina is secretly owned by Apple. At least, that would explain the company’s obvious joy at making their previous products look obsolete, and the way their competitors have to constantly protest that, yes, Illumina’s latest gadget is obviously very cool, but wouldn’t you like to compare prices and specifications? (This theory…
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NIH publishes first Alzheimer’s genomics dat…
The National Institutes of Health said Monday it has made available for researchers the first batch of genome sequence data from the Alzheimer’s Disease Sequencing Project (ADSP). Established in February 2012 by a Presidential Initiative, the ADSP is a national research project with the aim of finding ways to prevent or effectively treat the memory-stealing disease. Using large-scale genome sequencing, the National…
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Mechanical forces at work in living cells and tiss…
Don Ingber, of Harvard University’s Wyss Institute for Biologically Inspired Engineering, is a mechanobiologist – a member of the small but growing community of scientists who look at biological systems through the lens of physics. Mechanobiologists hope to add to our understanding of physiology, embryology, and disease ontogeny by observing the mechanical forces at work in living cells and tissues. Ingber sees this work…
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Bill would fast-track promising antibiotics for FD…
The antibiotics arena hasn’t proved lucrative enough for Big Pharma, leading to a mass exodus from the field in recent years. But pharma companies may have a reason to get back in the antibiotics game. A group of bipartisan members in the House of Representatives introduced a bill late Thursday that aims to combat the growing threat of so-called “superbugs” by essentially providing a fast-track route to FDA…
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Human, animal or plant mixed in new R&D recip…
Can a crop science team of ag-bio investigators provide some real insights that could help advance new drugs for humans and animals? Bayer believes so, and one of its top researchers says you can expect to see the first tangible fruits of its hybrid R&D effort in the next few years. Wolfgang Plischke, the outgoing tech/innovation chief at Bayer, told Reuters that “we expect it to be reflected in our pipeline in the…
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Major Update to the Human Reference Genome
The Genome Reference Consortium (GRC), the research collaborative responsible for maintaining a comprehensive reference genome for humans, mice, and zebrafish, has released its first complete update to the human reference genome in nearly half a decade. Reference genomes are crucial to genomic research, providing a baseline for assembling genetic fragments into a full picture of the genome, and comparing rare variants against…
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U.S. domination of global biomedical R&D slip…
Big Pharma’s decision to shift more of its R&D resources to Asia over the past few years has helped spur a subtle but significant erosion of the U.S.’s traditional dominance in the field. New research from the University of Michigan Health System shows that the U.S. share of the global biomedical R&D business declined to 45%–from 51%–between 2007 and 2012. And while Europe stayed steady at 29%,…

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Purity standards for reagents


Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications. Purity standards for reagents are set by organizations such as ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent…
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6th BioBanking event June 20-21 2016, Holiday Inn …
The upcoming proposed Data Protection Regulation in EU is the culmination of biobanking operations, and will constitute a new legal framework if and once passed by the European Commission. As such, SMi’s 6th Biobanking Conference will focus on the potential changes and impacts of maintaining a sustainable biobanking infrastructure, harmonisation and interaction between biobanks across UK, Europe and the world. Our expert…
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Academic Drug Discovery 2016 March 22-23 2016 Cam…
SELECTBIO is pleased to announce Academic Drug Discovery 2016, which will be held on 22 – 23 March 2016 in Cambridge, UK. The event is part of our Cambridge Workshop Series. Attracting a global audience of researchers, academics, group leaders, directors and the global heads of leading academic and open innovation drug discovery centres, this event will explore the current challenges and opportunities faced in academic…
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Stem Cells in Drug Discovery 2016 April 5-6 2016 ,…
In June 2015 we launched Stem Cells in Drug Discovery in Cambridge, United Kingdom to a great response!

You can check the Wikipedia reference about how stem cell banking is done and what its uses are. Stem cell banking or its preservation is a process by which the stem cell is extracted, processed and stored. The stem cells can be used in the future for treatment when it is required. The stem cells can get reformed to any tissue or to any organ in the body.

Featuring presentations from Lorenz Mayr, Joseph Wu and Chris Ward, over 90 people attended, from 9 different countries, including PhD students, Professors, Group Leaders, Directors, Global Heads and VPs of some of the world’s leading stem cell research centres. We are looking to build the event for 2016 with an…
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High Content & Phenotypic Screening 2016 on M…
This conference brings together researchers from both academia and industry, and will discuss the development of techniques and tools implemented in High Content technologies and Phenotypic Screening applications. Hot topics to be covered include 3D cell based screening methods, high content screening and data management, the use of model organisms and novel approaches for phenotypic screening. Attending this event will…
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Pain Therapeutics May 23-24 2016, London, UK
Many research studies show, pain is a significant source of suffering for many people and seriously affects their quality of life. Treatment of these patients is a great challenge and requires special approaches. SMi is proud to present the return of 16th Annual Pain Therapeutics to London, UK on 23-24 of May 2016. Through a series of interactive presentations and panel discussions, the event will introduce the insights from…
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5th annual ADC Summit London on May 23-24, 2016
SMi’s 5th annual ADC Summit provides a comprehensive analysis of the various approaches with the next generation ADCs. Hear the latest insights from Takeda on Adcetris; discuss the latest advancements in research and development from Medimmune; and analyse case studies from big pharma companies such as Roche, Bayer, Pfizer, AstraZeneca, Novartis and many more. Join industry experts as they share, confer and debate how…
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10th Annual Clinical Trial Logistics 2016 London o…
Registration is now live to attend the 10th annual Clinical Trial Logistics conference taking place in London on 18th & 19th May 2016. The implementation of Annex 15 of the Good Manufacturing Practice in Autumn 2015 provided a huge change in the regulatory landscape of the rapidly growing clinical trial supplies industry, with logistics and distribution services accounting for the largest share of the market. Clinical…
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Pre-Filled Syringes June 6-7th 2016, San Diego, US…
SMi proudly presents its inaugural event of the premier Pre-Filled Syringes series to San Diego in June 2016! The prefilled syringes (PFS) market is poised to account for exponential growth and account for $6 billion revenue by the end of 2020.* The market has witnessed continual advancements in device design with enhanced safety and usability by patients through human factor engineering. Nonetheless, challenges surrounding…
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ADMET June 13-14 2016, London, UK
SMi is proud to announce the return of the 11th annual ADMET conference 2016 in London! ADME and toxicology testing are one of the most important research activities related to new drug discovery. Ensuring a good ADMET study will accelerate approval and therefore commercialization of your drug product – and hence pharmacokinetics remain at the forefront of drug formulation and development Since the pharmaceutical and…
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16th International Symposium on Preparative and In…
The Scientific Committee is pleased to invite you to Vienna for the 16th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, SPICA 2016, which will take place from October 9-12, 2016 at the Austria Center Vienna. http://www.ldorganisation.com/v2/produits.php?langue=english&cle_menus=1238916108 …

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Purity standards


Grades of chemical reagents describe the sufficient purity for use in chemical reactions, chemical analysis, physical testing and various laboratory applications. Purity standards for reagents are set by organizations such as ACS(American Chemical Society), ASTM International, European Pharmacopeia. Some reagent grades are registered trademarks such as BAKER ANALYZED™, ULTREX®/ULTREX®, PHOTREX®. Below is a list of common reagent…
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Pan Omics Summit May 21-22,2015 Boston, MA
We invite you to the attend the Pan-Omics Summit, which will take place May 21 – 22, 2015 in Boston, MA at the Hyatt Regency. This summit has four parallel tracks to discuss the developments and challenges in the popular omics areas of epigenomics, metabolomics, functional genomics, and next generation sequencing. Representatives from big pharma, academic institutions, and government research labs will present data on…
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RICT 2015 Drug Discovery and Selection – Jul…
The French Medicinal Chemistry Society (Société de Chimie Thérapeutique – SCT) is pleased to invite you to Avignon on July 1-3, 2015, for the 51st edition of the International Conference on Medicinal Chemistry (RICT 2015). The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, will focus on “Drug Discovery and Selection – Understanding Targets and…
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Biophysics in Drug Discovery 2015 June 9-12, 2015 …
The use of biophysical techniques in drug discovery is rapidly increasing, and many pharmaceutical companies have set up in-house biophysical platforms to speed up the target-to-candidate process and improve the quality of small-molecule therapeutics through a better understanding of their interactions with their targets.Most of the pharmaceutical industries growth is because of increase in size of the global population which is ageing. This increases demand for long term treatment for many chronic diseases. It also offers better healthcare access in the emerging economics.Find out this here about the challenges of starting a pharmaceutical company. However, biophysics for drug discovery had not yet been the subject of a dedicated conference: most of…
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Bioheterocycles 2015 on June 7-11, 2015 Metz, Fran…
The XVI conference of this series will gather chemists from over the world, involved in the chemistry of heterocycles. The heterocycles in this case will generally be submitted to biological tests as well in medicine as in agriculture. The scientific programme will include plenary and invited lectures by top chemists in the field and will be completed by oral communications and poster presentations. The conference is intended…
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Paediatric Clinical Trials 25th – 26th March…
A large number of medicines used in paediactric care have not been tested on children and are therefore used off lable or unlicensed. This absence of suitable authorised medicinal products to treat conditions in children is an issue that has been of concern for some time, and one that is increasingly coming to the fore. Returning for its ninth year as an industry leading event, SMI are proud to present the 9th annual…
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International Conference on Geology on June 22-23,…
OMICS Group warmly welcomes you to the International Conference on Geology along with the external scientific association with the researches around the globe, scheduled on June 22-23, 2015 at Florida, USA. Geology-2015 will place a platform where renowned speakers and scientists across the globe will present their knowledge which will be helpful for the young researchers. The important features of this conference are well…
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Controlled Release Conference, 20th – 21st A…
As controlled release drug delivery systems continue to play an important role among the emerging areas of research in the treatment of diseases, this event will focus on specific topics looking at advances made in the field and how to overcome the challenges involved when developing controlled release formulations. Returning for its twelfth year and following on from the major success of previous events, SMi are proud to…
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Adaptive Designs in Clinical Trials 20th April to …
Prior to the approval of new drugs, substantial evidence of efficacy is required and safety brought through clinical trials. A massive decline in success rates in Phase II/III of clinical trials has resulted in only 1 in 10 drugs successfully passing through these trials in the US. With increasing pressure to bring drugs quickly into the market and reduce the cost of drug development, the paradigms of drug dosage…
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Society of Toxicology Annual Meeting & ToxExp…
The SOT Annual Meeting is the largest meeting of its kind. This annual event features a broad range of scientific sessions and a thematic program that provides partici-pants with a unique opportunity to deepen their knowledge in topical areas and interact with leaders in their respective disciplines. The scientific program includes a plenary session, the MRC Lecture, symposia, work-shops, roundtable discussions, informational…
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Immunotherapeutics & Immunomonitoring Confere…
GTC is proud to present the 7th Immunotherapeutics & Immunomonitoring Conference held on January 29-30, 2015 in San Diego, CA. Leading experts will present about novel findings and developments in the constantly changing area of immunological assays and procedures. They will also discuss recent advances in immunotherapy, as they relate to various immunotherapy modalities, specific cancers, cell subsets, animal models, and…

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Natural medicine or alternative medicine is a variety of therapeutic or preventive health care practices, such as homeopathy, naturopathy, chiropractic, and herbal medicine, that do not follow generally accepted medical methods and may not have a scientific explanation for their effectiveness.

Below is a list of some natural products intended to cure common medical conditions. They are available for sale from Russian Pharmacy.

Bilberry-Forte

The bilberry’s ability to improve vision is known in folk medicine for a long time and its fame was confirmed by numerous studies. Your eye is an important organ and it is essential that you take good care of it. The web link guides you on what you should do to maintain a healthy eye. Go for routine visits to improve the vision of your eye. Your diet should include plenty of vegetables and fruits. Do not ignore your sunglasses when you step outside. Bilberries improve eye acuity, reduce eye fatigue caused by continuous work under artificial lighting, accelerate renewal of retina, that is sensitive to light.

Bilberry-Forte contains bilberry fruits, vitamins B1, B2, B6, C, P, zinc (oxide), silicium (oxide), sugar, microcristalline cellulose.

Bilberry-Forte with Vitamins and Zinc is a balanced complex of vitamins, microelements and biologically active substances, necessary for daily support of vision and lowering risk of eye diseases. Biologically active substances of bilberry (anthocyanins, organic acids, carotenes, pectic substances, microelements), acting in complex with vitamins of group B, C, P and zinc:
– prevent eye fatigue, irritation and weakening of vision;
– improve vision adaptation to darkness;
– strengthen vascular walls, including eye grounds;
– have a positive effect for vitamins deficit and disorders connected with it;
– improve health in general.

Gepatrin

Gepatrin is a unique combination of components having hepatoprotector, holagogue and liver restoring properties.

Gepatrin contains silymarin (holy thistle), artichoke extract, essential phospholipids (lecithin) and vitamins B1, B2, B6, E.

The area of application of Gepatrin dietary supplement is determined by optimum combination of hepatoprotector activity of holy thistle, cholagogue activity of artichoke extract, and liver restoring activity of essential phospholipids.

Gepatrin contains three natural ingredients:

– extract from fresh artichoke leaves;
– sylimarin obtained from holy thistle extract;
– essential phospholipids (lecithin)

that provide triple protection of liver:
– they will extract toxins from the liver;
– they will protect liver cells against destroying;
– they will restore damaged liver cells.

Krasniy Koren(Red Root)

Krasniy Koren improves urination, promotes complete bladder emptying, decrease frequency of urination especially by night. Krasniy Koren promotes restoration of male sexual activity, improvement of blood circulation and elimination of prostate congestions, restoration of energy after exercise stress.

Each 0.4g tablet of Red Root contains:
– 372mg of Hedysarum neglectum roots (Red Root);
– 4mg of vitamin E (on the analogue of tocopherol);
– 6.25mg of zinc (oxide);
Inactive ingredients: calcium stearate, aerosil.

The flavonoids contained in Hedysarum as well as tannins, cumarins, triterpene saponins and other bioactive compounds exert an antiinflammatory, bactericidal, spasmolytic, vasorelaxant and mild diuretic activities. Zinc is the basic element taking part in synthesis of male sex hormone testosterone. The vitamin E and zinc possess antioxidant properties and prevent injuring body tissues caused by free radicals, promote functional restoration of male sexual glands functions and play an important role in preventing of prostate diseases.

In people with prostate inflammations and squeezed ducts caused by prostate adenoma the complex of bioactive compounds supports the urinary excretion system: improves urination, promotes complete bladder emptying, decrease frequency of urination especially by night. Krasniy Koren promotes restoration of male sexual activity, improvement of blood circulation and elimination of prostate congestions, restoration of energy after exercise stress.

The flavonoids contained in Hedysarum as well as tannins, cumarins, triterpene saponins and other bioactive compounds exert an antiinflammatory, bactericidal, spasmolytic, vasorelaxant and mild diuretic activities. Zinc is the basic element taking part in synthesis of male sex hormone testosterone. The vitamin E and zinc possess antioxidant properties and prevent injuring body tissues caused by free radicals, promote functional restoration of male sexual glands functions and play an important role in preventing of prostate diseases.

In people with prostate inflammations and squeezed ducts caused by prostate adenoma the complex of bioactive compounds supports the urinary excretion system: improves urination, promotes complete bladder emptying, decrease frequency of urination especially by night. Krasniy Koren promotes restoration of male sexual activity, improvement of blood circulation and elimination of prostate congestions, restoration of energy after exercise stress.

Krasniy Koren is a source of a wide complex of biologically active substances, such as tannins, determining areas of application of the preparation:
– symptoms of urogenital diseases;
– complex therapy of acute and chronic prostatitis and prostate adenoma;
– restoring male sexual performance.

Mumiyo Altayskoye

The Mummyo is a unique natural host resistance stimulator found in Altay Mountains.
It has been used by many folks since ancient times in treatment of wide range of diseases.

Mummyo contains a wide range of natural biological active substances, such as 30 micro- and macronutients in form of bioavailable organic compounds, 6 amino acids, several vitamins, essential oils, resinlike substances, which determine its applications variety.

Organic Acids take part in metabolic process, support acid-base balance, stimulate glands activity, promote lowering putrefaction processes in bowels.
Macro- and micronutrients also take part in important metabolic processes, such as water-salt metabolism, acid-base metabolism as well as ferment process. The basic mineral substances of mummyo, such as calcium, phosphorus, zinc take part in bone tissue forming. Furthermore,
Calcium takes part in normalizing arterial pressure, has favourable effect on neuromuscular and cardiovascular systems;
Phosphorus takes part in forming cell wall, heart, brain and muscles tissues, dissolves fats, proteins, carbohydrates;
Zinc strengthens immune and reproductive systems, improves memory, lowers cholesterine blood level;
Iron strengthens immune systems, takes part in producing hemoglobin;
Copper plays important role in maintaining proper heart functioning as well as healthy state of the bones, nerves, brain and erythrocytes.
Amino acids take part in protein and carbohydrate exchange, stimulate cardiovascular system, improve brain circulation and tissue trophism.

According to receipts of the Ancient Orient and to modern investigations mummyo can be widely used in following cases:
– complex treatment of fractures, injuries, burns;
– for gastric and duodenal ulcer;
– inflammatory diseases of gastrointestinal tract;
– for inflammatory diseases of upper and lower respiratory tracts;
– for inflammatory diseases of urogenital tract;
– for immunodeficiency;
– for skin diseases;
– for collapse, fatigue, stresses;
– in case of presence of unfavorable ecological conditions,
increasedradiation, chemical poisoning and other pathological factors.

Turboslim Day and Turboslim Night

Turboslim Day and Turboslim Night allow active weight loss 24 hours a day! Turboslim Day promotes fat burning acceleration, transforming fats into energy. Turboslim Night also increases metabolism and thermogenesis during sleep as well as acceleration of excessive fat utilization.

Turboslim Day – a formula of day action – is a source of flavonoids, caffeine, promoting fat burning acceleration, transforming fats into energy.

Turboslim Night – a formula of night action – is a source of hydroxy citric acid, B1, B2, E, L-carnitine, chrome, zink, promoting increasing metabolism and thermogenesis during sleep as well as acceleration of excessive fat utilization.

TURBOSLIM DAY
A bio-complex of day action to control weight, aimed to accelerate fat burning transforming fats into energy
Bioflavonoids of citrus plants stimulate thermogenesis and promote lowering depot fat. They exert the highest action in combination with caffeine.
Guarana extract provides optimal caffeine concentration level in the body, accelerates cell metabolism and metabolic processes, as well as increases thermogenic action of the citrus bioflavonoids.
Red Seaweed extract exerts drainage action: increases intertissue liquid circulation and extraction of the excessive liquids and toxins.
Bromeline and papain stimulate food digestion by enzymes converting it into the digestible components and preventing excesses.
Vitamins B3, C, zinc promote accelerating metabolism processes in the body.

TURBOSLIM NIGHT
A bio-complex of night action to control weight, allowing to use effectively the sleep not only for the purpose of rest, but also of active weight loss.
Garcinia cambodgia is a source of hydroxy citric acid decelerating conversion of excessive carbohydrates into depot fat and suppressing appetite.
Chitosan effectively binds fats and promotes their extraction out of the body.
Linoleic acid suppresses process of subcutaneous fat, promotes thermogeness (fat burning).
L-carnitine transports fats to the cell mitochondrions where they are converted into energy.
Senna extract improves digestion, increases activity of the large intestine, exerts a slight laxative action.
Melissa officinalis extract stimulates digestion, has antispasmodic and calming action.
Chromium picolinate supports normal physiological level of glucose in the blood, that promotes in its turn natural weight loss and suppressing the desire to eat sweet food.
Vitamins B, E, zinc take part in protein, fats and carbohydrate exchange.

List of other herbal medicines, dietary supplements and bioactive additives produced by Evalar. Contact Russian Pharmacy in USA for purchasing information.

Medicinal Agents >>>

Elixir Evalar – Medicinal elixir to strengthen your health!
Pantocrine – Stimulating mental and physical performance, unique source of adaptogens.
Pantocrine Tablets – Tableted form of Pantocrine.

Parapharmaceuticals >>>

Ateroklefit – Overall cleansing blood and vessels of cholesterol.
Preventing cardiovascular deseases, normalizing blood pressure.
Calcium Evalar – Unique composition of the product including Alpine mummyo provides 100% daily rate of calcium and vitamin D3.
Dihydroquercetin – Siberian cleanser for vessels.
Inulin Forte – Recommended for people with diabetes to improve carbohydrate metabolism.
Laminaria – Used for preventing diseases of thyroid gland, adenoma of thyroid.
Mummyo Altayskoye Ochishchennoye – Mummyo is a is a unique natural host resistance stimulator from Altay Mountains. It has been used from ancient times.
Phytolax – Natural laxative agent.
Sleep Formula – Has positive effect on falling asleep and sleep quality.

Altai Relic Herbs Line >>>

Agrimonia eupatoria – With antineoplastic properties.
Bupleurum – Used as cholagogue, succagogue agent.
Comarum palustre – Used for joint and spinal column diseases.
Euphrasia officinalis – Used for glaucoma and cataract.
Hedysarum neglectum – Used for prostatitis, it also can help improve potency.
Ortilia – Used for treating female diseases of different kind.
Pirola rotundifolia – With diuretic and antiseptic properties.
Rhodiola algida – Used for mastopathy, hysteromyoma, thyroid gland pathology.
Solidago virgaurea – Used as diuretic agent, solving kidney-stone, biliary and cystic calculus.

Plant Oils >>>

Fir Needle Oil – Strengthening body’s defences.
Siberian Pine Nuts Oil – Healing siberian product with unique properties.

Vitamins of Directed Action >>>

Vitevalar Vitamins for Eyes – New generation of vitamins!
Vitamins aimed to improve vision.
Vitevalar Vitamins for Brain New generation of vitamins!
Vitamins aimed to improve brain functioning.
Vitevalar Vitamins for Heart – New generation of vitamins!
Vitamins aimed to strengthen cardiovascular system.
Vitevalar Vitamins for Beauty – New generation of vitamins!
Vitamins for skin, hair and nails beauty.
Vitevalar Vitamins of Youth New generation of vitamins!
Vitamins aimed to decelerate aging.
Vitevalar Vitamins for Active Life Styles New generation of vitamins!
Vitamins aimed to increase the body’s energy for active life.
Vitevalar Vitamins for Cold New generation of vitamins!
This vitamin complex will support your health in the flu season.

Dietary Supplements for Eyes >>>

Bilberry-Forte Syrup – Imrpoving vision, lowering vision fatigue.
Bilberry-Forte – Bilberry-Forte for your vision!
The most popular means for eyes, helps managing vision loads.
Zvyozdnaya Ochanka – Superstar of your vision!
Reducing risk of visual impairment. Protecting against glaucoma and cataract.
Zvyozdnaya Ochanka Tea Drink – Eyebright is the most popular folk medicinal herb for eyes.

Dietary Supplements for Joints >>>

Chondro – Keep in motion with Honda!
Helps for arthritis and arthrosis, repairs cartilaginous tissue.
Chondro Cream – Keep in motion with Chondro!
Helps for arthritis and arthrosis, repairs cartilaginous tissue.
Phytodoctor Boswellia Cream – Helpful for pains caused by joint inflammations.
Phytodoctor Red Pepper Cream – Red pepper contained in cream has warming up effect and is helpful for neuralgia, radiculitis, myositis.
Sabrephyt – Cuts off pains in joints!
Helps managing disieases of joints and spinal cord.
Sabrephyt Cream – Cuts off pain in joints!
Helps managing disieases of joints and spinal cord.

Ginkgo Line >>>

Ginkgo Biloba – Evalar Improving memory, maintaning lucidity of mind, helps restoring after insult.
Ginkgo Biloba – Evalar Tea Drink Improving memory, maintaning lucidity of mind, helps restoring after insult.

Dietary Supplements for Woman >>>

Femywell – Start to live after 40!
Herbal alternative to hormonal agents.
Mastocaps – Suppresses prolactin formation, that is one of the causes of mastopathy.
Mastophyt Recommended for preventing and complex therapy of mastopathy.
Mastophyt Cream – Recommended for preventing and complex therapy of mastopathy.

Dietary Supplements for Men >>>

Prostasabal – Natural means for prophylaxis and treatment of prostatitis.
Red Root – Red Root for men!
For prostatitis, improving potency.
Yohimbe Forte Restoring and maintaining sexual functions.
Weight Control/

Organism Cleansing >>>

Ananas Extract – Burns fats, promotes digesting. Loose excessive kilos and centimeters!
Atsellit – Protect yourself against cellulitis from inside!
Chitosan-Evalar – Fat hunter!
Normalizing metabolic exchange, promoting weight loss.
Enzymcomplex – Dietary supplement for systemic enzymotherapy.
Helps adequately to make up a lack of enzymes.
Garcinia Extract – Effectively impairing appetite due to the maximum quantity of the active component in the single dose.
Garcinia-Forte – Grace of your dream!
Suppressing desire to sweet and foods, impairing appetite, burning fats, regulating metabolic exchange.
Garcinia-Forte Tea Drink – Grace of your dream!
Suppressing desire to sweet and foods, impairing appetite, burning fats, regulating metabolic exchange.
Green Tea Extract – Helps managing excessive weight.
Matefigurel Tea Drink – Promotes reduction in the sense of hunger.
MCC Ankir-B – Promotes stable weight loss, binds toxins, lowers sugar and cholesterol levels.
Triplex – Life without parasites!
Natural agent protecting against parasites (ascarids, threadworms, Lamlia).
Turboslim Day – Active weight loss 24 hours a day!
Turboslim Night – Active weight loss 24 hours a day!
Turboslim Coffee – Loose weight with pleasure!
Turboslim Cleansing Tea – Helps cleansing body from toxins and metabolic waste products, gives you feeling of lightness in the body!

For Alcohol and Narcotic Abuse >>>

Corrida+ – Enjoy victory over the last cigarette!
Narcophyt – Narcofit is effective for dysfunctions of alcoholic and narcotic origin.
Pari-Evalar – Dietary supplement for treatment and prevention of alcohol and drug addiction.

Hepatoprotectors >>>

Avenasol Gentle liver cleansing.
Artichoke Extract – With cholagogue, hepatoprotector and slight diuretic action.
Hepatrin – Protects liver in three ways:
1. Protects liver cells against destroying.
2. Restores damaged liver cells.
3. Regulates bile production and outflow.
Holy Thistle Extract Reliable protector of liver.

Curative Cosmetics >>>

Anti-Herpes Lipstick – Used for prevening and treating herpes.
Burdock Oil – Traditional russian means recovering hair health.
Burdock Oil with Ginkgo Biloba – Improving circulation, strengthening hair roots.
Burdock Oil with Calendula and Hop Preventing hair loss. Recommended for people with tendency to alopecia.
Burdock Oil with Beggars-ticks Extract – Eliminating desquamation and allergic reactions of skin.
Burdock Oil with Propolis Extract – Preventing fragility of dry and damaged hair, protecting hair along the whole its length.
Burdock Oil with Horsetail Extract (with ceramids) Restoring hair structure, increase its strength and elasticity.
Burdock Oil with Tea Tree Extract With anti-seborrhea effect.
Burdock Oil with Nettle Extract Stimulating hair growth, strenghtening roots.
Endokrinol Cream-gel – Normalizing functioning of thyroid gland.
Venokorset Gel – French formula of smooth and beauty legs!
Venocorset – French formula of smooth and beauty legs!

Complex Phytopreparations >>>

Milona 1 for Respiratory System – Recommended for acute and chronic bronchitis, bronchial asthma and other diseases of respiratory system.
Milona 5 for Woman – Recommended for treatment of mastopathy and other female diseases.
Milona 6 for Joints – Recommended for use in acute and chronic joint and spinal colmn diseases.
Milona 8 with Sedative Action – Herbal complex with sedative action.
Milona 9 for Cardio-Vascular Health – Recommended for use in treatment of functional state of cardiovascular system.
Milona 10 for Liver Protection – Recommended for acute and chronic hepatitis, cirrhosis, chronic cholecystitis, cholelithiasis and dyskinesia of biliary tracts.
Milona 11 for Men – Recommended for use in prophylaxis and treatment of prostatitis and adenoma of prostate.
Milona 14 for Kidneys – Improving functioning state of kidney and urinary excretion system.

Traviata Tea Drinks Line >>>

Traviata – Herbs for Heart Helps improving cardiovascular functioning.
Traviata – Herbs for Blood Pressure Lowering Promotes lowering blood pressure and improving state of vessels.
Traviata – Diuretic Herbs – With diuretic action.
Traviata – Herbs for Appetite Lowering – Promotes lowering appetite, suppressing desire to sweet and foods.
Traviata – Herbs for Digestive Cleansing – Promotes improving gastrointestinal functioning.
Traviata – Herbs for Eyes Preventing vision fatigue, with antiinflammotary effect.
Traviata – Herbs for People with Diabetes Lowering sugar blood level.
Traviata – Gynaecological Herbs – Used in gineacological inflammatory diseases.
Traviata – Herbs for Veins – Improves state of venous vessels.
Traviata – Herbs for Joints – Improving functional state of vessels.

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National Institute of Health

NIH Roadmap for Medical Research

Director’s Transformative R01 (T-R01) Awards

Pioneer Awards 2009

New Innovator Awards 

NIH Administrative Supplement (Economy Stimulus Funding)

NIH Small Business Funding Opportunities

Small Business Innovation Research (SBIR)

SBIR Coach

SBIR Resource Center

Community of Science (COS) Funding Opportunities

The National Institute of Standards and Technology (NIST) Funding Opportunities

NIST Information Related to the American Recovery and Reinvestment Act of 2009

Department of Defense Funding Opportunities

The Bill & Melinda Gates Foundation Grant Opportunities

The Michael J. Fox Foundation for Parkinson’s Research

Multiple Myeloma Research Foundation (MMRF)

John Templeton Foundation

The European Commission and The European Federation of Pharmaceutical Industries and Associations (EFPIA)

Innovative Medicines Initiative: €246 Million to Support Public-Private Research Cooperation for a Fast Development of Better Medicines 

Leading venture capital firms focusing on life-science R&D according to FierceBiotech listing.

Domain Associates
Founded in 1985, Domain Associates, L.L.C. is a venture capital firm with an exclusive focus on life sciences. With $2.5 billion of capital under management, Domain is headquartered in Princeton, NJ with a second office in San Diego, CA. Domain’s three major investment segments are pharmaceuticals, specialty pharmaceuticals, and medical devices, while additional areas of interest include biomaterials, bioinstrumentation, and diagnostics. The Partners of Domain have a total of close to 200 person-years of experience among them in the healthcare/venture capital industries and have been involved in the formation and growth of more than 220 life-sciences companies. The highly focused network, experience, and reputation of this team have made it one of the top private-equity groups participating in the healthcare field.

HealthCare Ventures
HealthCare Ventures is a leading life science venture capital firm investing in pre-clinical or early clinical stage, project-focused companies with potential to transform patient care.

Technology is paying a great role in making healthcare assessable as well as affordable to all. It is very important that to provide excellent care to patients you need to develop understanding, patience, sympathy and compassion towards them. Pay attention to all the details that they want to share and try to make the visit a memorable one for them. This is a review on the healthcare system.

Technology is paying a great role in making healthcare assessable as well as affordable to all. It is very important that to provide excellent care to patients you need to develop understanding, patience, sympathy and compassion towards them. Pay attention to all the details that they want to share and try to make the visit a memorable one for them. This is a review on the healthcare system.

HCV approach is to identify high potential products within academia or pharmaceutical companies, develop them to clinical proof-of-concept within capital efficient, semi-virtual organizations, and generate superior returns through acquisitions by pharmaceutical and biotechnology companies

Polaris Venture Partners
Polaris Venture Partners is a partnership of experienced venture capital investors and technology executives. Our mission is to identify and invest in seed, first round, and early stage technology and life science businesses with exceptional promise and help them grow into sustainable, market-leading companies. In addition, Polaris is committed to providing growth equity and shareholder liquidity to established companies in the technology, healthcare, manufacturing, media, communications, and business services sectors. As a national venture capital firm with offices in the high-tech centers of Boston and Seattle, we’re able to invest in businesses throughout the United States and around the world. The firm has over $3 billion under management and current investments in more than 100 companies.

MPM Capital
MPM Capital is one of the world’s largest life science-dedicated venture investors. With committed capital under management in excess of $2 billion, MPM Capital is uniquely structured to invest globally in healthcare innovation.

Alta Partners
Alta Partners is a leading venture capital firm in life sciences, funding over 130 companies in the industry since 1996. The diverse and integrated team brings together a powerful depth of knowledge and experience, delivering tangible results for our companies and our investors.
Alta is committed to building successful businesses through deep collaborative partnerships with outstanding entrepreneurs. Alta invests only in those areas where it has specific domain expertise.

ARCH
ARCH invests primarily in companies co-founded with leading scientists and entrepreneurs, concentrating on bringing to market innovations in life sciences, physical sciences, and information technology. The firm enjoy special recognition as a leader in the successful commercialization of technologies developed at academic research institutions and national laboratories.

Flagship Ventures
Flagship Ventures is a venture capital firm focused on creating, financing and building innovative companies. Founded in 2000, Flagship manages over $600 million in early-stage funds and operates from its offices at Kendall Square in Cambridge, MA. With an active portfolio of over 40 companies, the firm’s strategy is to balance its investments across three principal business sectors: Therapeutics, Life Science Tools & Diagnostics, and BioEnergy/Cleantech.

SV Life Sciences
SV Life Sciences is a leading international life sciences venture capital firm. SVLS affiliated funds have been investing in life sciences companies since the early 1980s and the firm closed its first dedicated life sciences fund in 1994. The SVLS team manages six venture capital funds and a publicly traded investment trust with approximately $2 billion of capital under management. The firm employs a diversified strategy within life sciences in order to selectively capitalize on an expanding opportunity in biotech, medical devices and health-care services. SVLS has offices in Boston, London and San Francisco.

Sanderling
Founded in 1979, Sanderling is among the oldest investment firms dedicated to building new biomedical companies. Sanderling demonstrates that significant companies are best built in close working partnerships with entrepreneurs. Sanderling’s unique approach combines a specialized investment focus with active management and long-term commitment to ensure the highest rates of return for both its entrepreneurs and investors. Biomedical investing has been a viable sector in the technology markets for more than thirty years, and in the past ten years has experienced accelerated growth. Since its inception, Sanderling has supported over 90 biomedical companies from very early stage start-ups, through commercial development, earning consistently high rates of return on its venture investments.

Kleiner Perkins Caufield & Byers
Kleiner Perkins Caufield & Byers are passionately committed to helping their portfolio companies succeed. Entrepreneurs gain access to their matched portfolio of companies and associations with global business leaders. These relationships are the foundation for strategic alliances, partnership opportunities and the sharing of insights to help build new ventures faster, broader and with less risk.

InterWest Partners
For more than 30 years InterWest has partnered with exceptional entrepreneurs to build winning technology and life sciences companies. With more than 200 years of combined operating and investing experience, our team has raised $2.8B, completed more than 70 IPOs, and participated in nearly 60 upside acquisitions. As we invest InterWest X, a $650M fund, Partners continue to believe that providing capital is just the beginning of a long-term collaboration with entrepreneurs to turn their vision into a thriving company.

Sofinnova Ventures
Sofinnova Ventures has over 30 years of experience building start-ups and spin-outs into market leaders. With $1 billion under management, the firm applies capital and expertise to guide early stage companies to successful exits.

Burrill Venture Capital
The Burrill family of venture capital funds includes funds with more than $950 million under management. These funds were formed to capitalize on Burrill’s unique investment platform and the opportunities created by today’s intersection of the genomic/proteomic and biologic revolution, and capital market inefficiency occurring within the life science field.

New Enterprise Associates
For more than 30 years, NEA has been helping to build great companies. NEA’s committed capital has grown to $11 billion and it’s funded more than 650 companies in the Information Technology, Energy Technology and Healthcare sectors. With more than 65 investment professionals working out of offices in the US, India, and China and investing across the globe—NEA is the entrepreneur’s venture capital firm, consistently ranking among the top firms in portfolio IPOs each year. Since its founding, the firm has backed more than 165 companies that have gone public and invested in more than 255 companies that have been successfully merged or acquired—more liquidity events than any other venture capital firm.

OrbiMed
OrbiMed is the world’s largest healthcare-dedicated investment firm, with approximately $5 billion in assets under management. OrbiMed’s investment advisory business was founded in 1989 with a vision to invest across the spectrum of healthcare companies: from private start-ups to large multinational companies. OrbiMed manages the Caduceus Private Investments series of venture capital funds and a family of public equity investment funds. OrbiMed’s investment team includes over 35 experienced professionals with backgrounds in science, medicine, industry, finance, information technology and law.

Quaker BioVentures
Quaker BioVentures is a venture capital firm investing in life science companies. The firm leads investments across the spectrum of the life science industry, including biopharmaceuticals, medical devices, human diagnostics, specialty pharmaceuticals, and healthcare services. Quaker BioVentures invests in companies at all stages of development, from early stage start-ups to public companies. Founded in 2003, the firm is currently investing Quaker BioVentures II, a $420 million fund formed in 2007. Quaker BioVentures manages over $700 million in committed capital.

Venrock
Venrock was founded in 1969 as the venture capital arm of the Rockefeller Family and we have $2.2 billion under management. Venrock provides funding and services for entrepreneurs with breakthrough ideas in technology, healthcare, media and energy. Venrock’s entrepreneurs have charted new advancements in cancer and HIV treatments, powered semiconductors and the digital era, secured our information technology infrastructure, pioneered on-line advertising, delighted consumers and most recently, generating power through alternative means. Venrock’s 22 investment professionals currently back 117 ventures out of offices in Palo Alto, New York City, Cambridge, and Israel.

More venture companies:

Aberdare Ventures
Abingworth
Aeris CAPITAL
Aisling Capital
Anthem Capital
Alliance Technology Ventures
Apple Tree Partners
Edmond de Rothschild Investment Partners
Bay City Capital
Bessemer Venture Partners
Care Capital
Caxton Advantage Life Sciences Fund
Chicago Growth Partners
Clarus Ventures
DAG Ventures
Delphi Ventures
Devon Park Bioventures
Enterprise Partners Venture Capital
Essex Woodlands Health Ventures
Excel Medical Fund
Frazier Healthcare Ventures
Grupo Cornelio Brennand
HBM BioCapital
HBM BioVentures
Highland Capital Partners
Intersouth Partners
Khosla Ventures
McNerney & Partners
MDV-Mohr Davidow Ventures
Morningside Venture
MVM Life Science Partners
Naxos
Northgate Capital
Novo A/S
Osage Partners
OVP Venture Partners
Oxford Finance Corporation
Panorama Capital
ProQuest Investments
Prospect Venture Partners
Rho Capital Partners
Scale Venture Partners
Sectoral Asset Management
SR One, the corporate venture fund of GlaxoSmithKline
Sutter Hill Ventures
Teachers’ Private Capital
The Column Group
Thomas
TPG Biotech
Venrock Associates
Ventech
Versant Ventures
Votorantim Novos Negocios
Wellcome Trust
Ysios Capital Partners

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The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway.

Jiang J, Sugimoto Y, Liu S, Chang HL, Park KY, Kulp SK, Lin YC.

Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA.

BACKGROUND: Racemic gossypol [(+/-)-GP], a naturally occurring polyphenolic yellow pigment present in cottonseed products, inhibits in vitro proliferation of Dunning prostate cancer cells (MAT-LyLu),Cottonseed oil is used mainly to make processed food. Visit this site right here to know of products that use cottonseed oil. Cottonseed oil can extend the shelf life of the food products. Margaraine, potato chips and salad dressing commonly use cottonseed oil. The oil is also used in baking. It helps to get a creamy consistency in the icing as well. However since cottonseed oil is high in the saturated fat it raises the cholesterol level. human prostate cancer cells derived from a bone marrow metastasis (PC3), MCF-7 and primary cultured human prostate cells. (+/-)-GP also has the ability to inhibit the metastasis of lung and lymph nodes of the androgen-independent rodent prostate cancer cell line, MAT-LyLu, after implantation into Copenhagen rats. MATERIALS AND METHODS: The effects of (+/-)-GP on the proliferation of human prostate cancer PC3 cells were determined by thymidine incorporation assay and doubling-time (DT) determination. The mechanisms of action of (+/-)-GP on the proliferation of PC3 cells were determined by RT-PCR analysis, ELISA assay and Western blot analysis. RESULTS: The results show that (+/-)-GP caused reductions in DNA synthesis and prolonged the DTs in PC3 cells. RT-PCR and ELISA results show that (+/-)-GP elevate the mRNA expression and protein secretion of transforming growth factor beta1 (TGFbeta1) in PC3 cells. Consistent with these findings, (+/-)-GP has been shown to decrease the cyclin D1 mRNA expression and protein expression in PC3 cells. Furthermore, the growth inhibition of PC3 cells by conditioned media collected from the (+/-)-GP-treated-PC3 cells was completely reversed by addition of 25 microg/ml of mouse monoclonal anti-TGFbeta1, -beta2, -beta3 antibody, suggesting the involvement of TGFbeta1 in (+/-)-GP-induced growth inhibition of PC3 cells. CONCLUSION: These results indicate that the inhibitory effects of (+/-)-GP on the proliferation of human prostate cancer PC3 cells are associated with induction of TGFbeta1, which in turn influences the expression of the cell cycle-regulatory protein, cyclin D1, in prostate cancer cells.

PMID: 15015581 [PubMed – indexed for MEDLINE]

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Cottonseed Drug Boosts Cancer Treatment in Mice

Gossypol, a drug refined from cottonseed oil, and previously tried and abandoned as a male contraceptive, could boost the effectiveness of treatment for prostate cancer and possibly other common cancers as well.

New York /PSA Rising/ October 5, 2004 — Gossypol, a drug made from a toxic yellow pigment in cottonseed, for about a decade has been tested for use against prostate and other cancers.

Gossypol in cotton is a natural toxin present in the plant that protects it from insects. Its name is derived from the scientific name of cotton ( Gossypium spp.) and phenol, its main chemical structure.

Did you know that you can also trade in cotton? The commodity market lets you trade on the cotton price. You can do this online. Buy the cotton futures contract if you think that the price will go up in the future. Sell the futures contract if you think that the price may fall.Look at here for tips to trade cotton.

Cottonseed can poison cattle yet gossypol is an old, abandoned male contraceptive used in China in the 1920s. After studies in the 1970s it was abandoned because some men remained infertile after stopping treatment and some developed hypokalemia (potassium shortage in the blood, which can lead to serious heart problems). Although in 1998 the World Health Organization said research on its use for contraception should be abandoned, Chinese researchers are still testing low-doses.

New interest has developed in gossypol as an anti-cancer drug. Gossypol is able to inhibit growth of a wide range of cancer cells both in a lab dish (in vitro) and in mice and other lab animals (in vitro). A study in Ohio in 1996 of the effect of gossypol on the growth of human androgen-independent prostate cancer cell line (PC3) found that gossypol “is a potent inhibitor of prostate cancer cell growth.”

Natural gossypol (GP) is made up of two mirror image molecules (enantiomers) — (+)GP (plus gossypol) and (-)GP (minus gossypol). Tests on breast cancer cells have shown that (-)GP is the more potent inhibitor of cancerous breast cell growth (Anticancer Res. 2002 Jan-Feb).

Now researchers at the University of Michigan Comprehensive Cancer Center say that minus gossypol (-)GP inhibits the function of Bcl-2/xL in human prostate tumors implanted in mice and makes the cancer more sensitive to radiation therapy and chemotherapy. The drug increased apoptosis, or programmed cell death.

“The significance of this is that anti-apoptotic proteins Bcl-2 and Bcl-xL are over expressed in many cancers, making them resistant to drug and radiation treatment. So, it is not just prostate cancer that our findings are relevant to, but also other cancers with BcL-2/xL expression, such as those of the lung, breast, ovary, pancreas, skin, brain and head and neck, where (-)-gossypol may also sensitize cancer cells to chemotherapy or radiation,” says Liang Xu, M.D., Ph.D., research assistant professor in hematology and oncology at the U-M Medical School.

Based on the cell and animal data, the (-)-gossypol form of the drug was likely to be more active than the same doses of natural gossypol used in previous studies. Furthermore, cell and animal data show that (-)-gossypol would make radiation and chemotherapy more powerful and overcome the resistance to drug and radiation treatment caused by high levels of Bcl-2/xL.

Gossypol is not the first drug investigated as a contraceptive to find a potential role in treating cancer. Tamoxifen was first developed as a female contraceptive and failed, only to become the world’s most successful breast cancer drug.

Will gossypol follow in the footsteps of tamoxifen? “There is a lot of research still to do, but we certainly hope so,” Xu says. “The natural form of gossypol has been extensively tested in humans and is well tolerated for long-term use. If we use the more active form, (-)-gossypol, correctly and wisely – for example, in combination with radiation or chemotherapy – gossypol may soon find its new role in our fight against cancer.”

Xu says he hopes to see the findings clinically tested soon and a Phase I trial is planned.

The research team is led by Marc Lippman, M.D., John G. Searle Professor and chair of internal medicine, and Shaomeng Wang, Ph.D., associate professor of internal medicine and co-director of the U-M Comprehensive Cancer Center Experimental Therapeutics Program, in collaboration with Theodore Lawrence, M.D., Ph.D., Isadore Lampe Professor and chair of Radiation Oncology.

Results of the Michigan study were reported Oct. 1 at the Symposium on Molecular Targets and Cancer Therapeutics in Geneva, Switzerland. The symposium is sponsored by three major cancer organizations: European Organization for Research and Treatment of Cancer, the National Cancer Institute and the American Association for Cancer Research.

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